8HAH

Cryo-EM structure of the p300 catalytic core bound to the H4K12acK16ac nucleosome, class 2 (3.9 angstrom resolution)

Exp. Method EM
Resolution, Å 3.9
Release Date 2023-05-17
Update Date 2023-07-26
Authors Kikuchi, M., Morita, S., Wakamori, M., Sato, S., Uchikubo-Kamo, T., Suzuki, T., Dohmae, N., Shirouzu, M., Umehara, T.
Publication PMID: 37460559
doi 10.1038/s41467-023-39735-4
RCSB PDB 8HAH
EMDB EMD-34589
Q-score 0.159
Core histones in Nucleosome-like particles:
Side Chain HistoneDB Variant Taxa UID
H3 Proximal A canonical H3 Homo sapiens P68431
Distal E canonical H3 Homo sapiens P68431
H4 Proximal B canonical H4 Homo sapiens P62805
Distal F canonical H4 Homo sapiens P62805
H2A Proximal C canonical H2A Homo sapiens P04908
Distal G canonical H2A Homo sapiens P04908
H2B Proximal D canonical H2B Homo sapiens P06899
Distal H canonical H2B Homo sapiens P06899
Other proteins:
Chain Name UID
K Histone acetyltransferase p300 Q09472
DNA:
Chain Variant Length
I alphasat_146 164
J alphasat_146 164

H3

H4

H2A

H2B

DNA

Other


Aligned nucleosome coordinates

Nucleosome reference frame definition

DNA relative twist and local base step parameters

Sequence on X-axis is numbered relative to the dyad base pair.

Atomic contacts between nucleosomal entities.


Hover the mouse cursor on the barplot to show contact information. Oncogenic mutations of non-histone proteins in contact are highlighted.